Description
Clenbuterol® acts through selective stimulation of the β2-receptors. It differs from other β2-specific sympathomimetic by the low effective dose, long biological half-life, rapid and complete absorption by oral administration. It has properties similar to those of salbutamol. It is used as a bronchodilator in the management of reversible airways obstruction, as in asthma and certain patients with chronic obstructive pulmonary disease.
Pharmacokinetics
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Absorption: Rapid oral absorption
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Onset of action: 30–60 minutes
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Peak plasma levels: 2–3 hours post-dose
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Half-life: ~36–48 hours (long half-life is why it’s often dosed once daily)
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Excretion: Primarily renal (urine); unchanged drug excreted
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Metabolism: Minimal hepatic metabolism; mainly excreted unchanged
2. Dosage & Usage
⚠️ Note: Clenbuterol should be used with extreme caution due to its potent stimulant effects and potential risks.
Typical Dosage (for performance/fat loss purposes):
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Starting dose for men: 20–40 mcg/day
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Starting dose for women: 10–20 mcg/day
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Titration: Increase by 20 mcg every 2–3 days, depending on tolerance.
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Max dose: 120–140 mcg/day (do not exceed)
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Cycle Duration: Typically 2 weeks on, 2 weeks off (to prevent receptor downregulation) OR 2-day on / 2-day off cycling method.
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Cycle Length: 4–8 weeks max; longer use increases risks significantly.
Example Clenbuterol 2-week Pyramid Cycle:
Day Dosage 1–2 20 mcg 3–4 40 mcg 5–6 60 mcg 7–8 80 mcg 9–10 100 mcg 11–12 80 mcg 13–14 60 mcg Some users also stack with Ketotifen to extend cycle length and maintain receptor sensitivity.
3. Side Effects
Common Side Effects:
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Tremors/shakiness
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Increased heart rate (tachycardia)
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Nervousness, anxiety
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Sweating
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Insomnia
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Muscle cramps
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Headaches
Less Common but Serious Side Effects:
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Heart palpitations
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High blood pressure
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Cardiac hypertrophy (especially with long-term use)
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Arrhythmias
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Electrolyte imbalance (especially potassium loss)
Important: Always monitor heart rate and blood pressure during use.
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