Description
๐ Description
Adenosine Monophosphate (AMP) is a nucleotide composed of an adenine base, ribose sugar, and one phosphate group. It plays a role in various biochemical pathways, including energy metabolism, RNA synthesis, and as a precursor to other nucleotides like ADP and ATP. In clinical or veterinary use, AMP may be used for:
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Energy metabolism support
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Muscle recovery
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Cellular regeneration
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Potential immune or anti-inflammatory support (investigational)
Formulation:
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Concentration: 30 mg/mL
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Route: Typically intramuscular (IM) or subcutaneous (SC) injection
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Commonly available in vials for injection
๐ Dosage & Administration
Dosage depends on the indication and species (human or veterinary), but generally:
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Humans (off-label/nutritional use):
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1โ2 mL IM, 1โ2 times per week (depending on clinical judgment)
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Veterinary use (e.g., horses, dogs):
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Horses: 5โ10 mL IM or SC
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Dogs/Cats: 0.5โ2 mL IM or SC
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Frequency: Once daily or every other day, usually in cycles
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Note: AMP is not widely approved by regulatory bodies like the FDA for direct human therapeutic use, except in research or nutraceutical contexts. Consult a healthcare professional before use.
โ ๏ธ Side Effects
Though generally considered safe at recommended doses, possible side effects include:
Common (mild)
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Local irritation at injection site
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Mild fatigue
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Headache
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Nausea or mild GI upset
Rare (moderate-severe)
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Allergic reaction (rash, itching, swelling)
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Hypotension (in high doses)
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Tachycardia or palpitations (if AMP is rapidly metabolized to adenosine)
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Dyspnea or chest discomfort (rare, typically at very high doses)
๐งช Pharmacokinetics
AMP is a naturally occurring compound, so its metabolism and clearance are relatively rapid and integrated with normal cellular processes.
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Absorption: Rapid after IM or SC administration
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Distribution: Widely distributed across tissues; quickly taken up by cells
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Metabolism:
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Primarily in the liver and cells, converted to adenosine, ADP, and ATP
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Adenosine is then further broken down by adenosine deaminase to inosine
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Elimination half-life: Very short (minutes), especially once converted to adenosine
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Excretion: Metabolites are excreted in urine (e.g., hypoxanthine, uric acid)
๐ Additional Notes
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Drug Interactions: Minimal, but theoretically may interact with adenosine antagonists (like caffeine, theophylline) or antihypertensives
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Contraindications:
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Known hypersensitivity
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Severe hypotension or bradycardia
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Active infection or inflammation at injection site
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Pregnancy/Lactation: Safety not well-established
Reviews
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